Advanced Statistics in Regulatory Critical Clinical Initiatives is focused on the critical clinical initiatives introduced by the 21st Century Cure Act passed by the United States Congress in December 2016. The book covers everything from the outline of the initiatives to analysis on the effect on biopharmaceutical research and development. Advanced Statistics in Regulatory Critical Clinical Initiatives provides innovative ways to resolve common challenges in statistical research of rare diseases such small sample sizes and provides guidance for combined use of data. With analysis from regulatory and scientific perspectives this book is an ideal companion for researchers in biostatistics, pharmaceutical development, and policy makers in related fields. Key Features: Provides better understanding of innovative design and analysis of each critical clinical initiatives which may be used in regulatory review/approval of drug development. Makes recommendations to evaluate submissions accurately and reliably. Proposes innovative study designs and statistical methods for oncology and/or rare disease drug development. Provides insight regarding current regulatory guidance on drug development such as gene therapy and rare diseases.

Over the last decade, an unprecedented expansion in the field of nanomedicine has resulted in the development of new nanomaterials for diagnosis and therapy of various diseases such as cancer. This book covers the design, synthesis and applications of various functionally-hybridized nanomaterials for biomedical applications. It includes strategies for design and synthesis of hybrid nanomaterials, surface engineering of various nanoparticle-based hybrid nanosystems for cancer imaging and therapy, toxicity aspects of nanomaterials and the challenges in translation research of hybrid nanomaterials.

A comprehensive overview of both traditional and current knowledge on the health effects of plant based antioxidants, this book reviews medicinal and aromatic plants from around the world. It covers the different sources of antioxidants including essential oils, algae and marine microorganisms, as well as the role of abiotic and biotic stresses, endophytes, transgenic approaches in scavenging ROS and antioxidant plants used in different therapeutic systems.

A comprehensive overview of both traditional and current knowledge on the health effects of plant based antioxidants, this book reviews medicinal and aromatic plants from around the world. It covers the different sources of antioxidants including essential oils, algae and marine microorganisms, as well as the role of abiotic and biotic stresses, endophytes, transgenic approaches in scavenging ROS and antioxidant plants used in different therapeutic systems.

Do our ideas about social movements travel successfully beyond the democratic West? Unrest in China, from the dramatic events of 1989 to more recent stirrings, offers a rare opportunity to explore this question and to consider how popular contention unfolds in places where speech and assembly are tightly controlled. The contributors to this volume, all prominent scholars of Chinese politics and society, argue that ideas inspired by social movements elsewhere can help explain popular protest in China.

Drawing on fieldwork in China, the authors consider topics as varied as student movements, protests by angry workers and taxi drivers, recruitment to Protestant house churches, cyberprotests, and anti-dam campaigns. Their work relies on familiar concepts such as political opportunity, framing, and mobilizing structures while interrogating the usefulness of these concepts in a country with a vastly different history of class and state formation than the capitalist West. The volume also speaks to silences in the study of contentious politics (for example, protest leadership, the role of grievances, and unconventional forms of organization), and shows that well-known concepts must at times be modified to square with the reality of an authoritarian, non-western state.

​ The recent and dramatic development of China’s economy and international political muscle is especially pronounced in the country’s video game industry. Now the largest of its kind in the world by gross revenue, the Chinese video game industry impacts every player in the global game market and has begun to directly influence the nature of the video game medium itself. From its conceptualization of the player as a category and commodity, to its approach to the design, development, and marketing of products and services, the Chinese game industry is engaging in a complex, innovative, and fascinating reimagining of the video game as a cultural and industrial force. The purpose of The Chinese Video Game Industry is to help introduce and investigate this industrial and cultural powerhouse. The book’s contributors array the industry across its history, economics, organization, politics, and cultures, documenting its rise, exploring its operational, cultural, and aesthetic characteristics, and capturing its context vis-à-vis the global media landscape. In so doing, the contributors provide a robust resource for anyone interested in studying, building, or even simply appreciating games.

Over the last decade, an unprecedented expansion in the field of nanomedicine has resulted in the development of new nanomaterials for diagnosis and therapy of various diseases such as cancer. This book covers the design, synthesis and applications of various functionally-hybridized nanomaterials for biomedical applications. It includes strategies for design and synthesis of hybrid nanomaterials, surface engineering of various nanoparticle-based hybrid nanosystems for cancer imaging and therapy, toxicity aspects of nanomaterials and the challenges in translation research of hybrid nanomaterials.

This book focuses on the fundamentals, technologies and properties of ion irradiation of dielectric materials (e.g. glasses, crystals) with regard to various photonic applications. It introduces readers to diverse ion-beam techniques for the fabrication and modification of micron- or nanoscale photonic structures, including optical waveguides, photonic crystals, and nanoparticle (nano-spheres and nano-rods) systems, and presents state-of-the-art advances in this multi-disciplinary research field, demonstrating the unique capabilities of ion-beam technologies in optical dielectric materials processing. The book discusses in detail the properties of ion-beam processed waveguides, as well as the modification of dielectrics for photonic applications, such as electro-optic modulation, nonlinear frequency conversion, waveguide amplification and lasing. It also explores synthesis and the correlated optical effects of nanoparticles by ion beams, and features examples of successful micro- and nano-photonic devices. Given its breadth of coverage, the book will particularly appeal to readers interested in ion-beam technology, materials science, and integrated optics.

This book focuses on the fundamentals, technologies and properties of ion irradiation of dielectric materials (e.g. glasses, crystals) with regard to various photonic applications. It introduces readers to diverse ion-beam techniques for the fabrication and modification of micron- or nanoscale photonic structures, including optical waveguides, photonic crystals, and nanoparticle (nano-spheres and nano-rods) systems, and presents state-of-the-art advances in this multi-disciplinary research field, demonstrating the unique capabilities of ion-beam technologies in optical dielectric materials processing. The book discusses in detail the properties of ion-beam processed waveguides, as well as the modification of dielectrics for photonic applications, such as electro-optic modulation, nonlinear frequency conversion, waveguide amplification and lasing. It also explores synthesis and the correlated optical effects of nanoparticles by ion beams, and features examples of successful micro- and nano-photonic devices. Given its breadth of coverage, the book will particularly appeal to readers interested in ion-beam technology, materials science, and integrated optics.

Smart Homes (SH) offer a promising approach to assisted living for the ageing population. Yet the main obstacle to the rapid development and deployment of Smart Home (SH) solutions essentially arises from the nature of the SH field, which is multidisciplinary and involves diverse applications and various stakeholders. Accordingly, an alternative to a one-size-fits-all approach is needed in order to advance the state of the art towards an open SH infrastructure. This book makes a valuable and critical contribution to smart assisted living research through the development of new effective, integrated, and interoperable SH solutions. It focuses on four underlying aspects: (1) Sensing and Monitoring Technologies; (2) Context Interference and Behaviour Analysis; (3) Personalisation and Adaptive Interaction, and (4) Open Smart Home and Service Infrastructures, demonstrating how fundamental theories, models and algorithms can be exploited to solve real-world problems. This comprehensive and timely book offers a unique and essential reference guide for policymakers, funding bodies, researchers, technology developers and managers, end users, carers, clinicians, healthcare service providers, educators and students, helping them adopt and implement smart assisted living systems.

Antenna Mutants, Domestication, by Roberto Bassi Heterotrophic Cultivation, by William McCaffrey Chlorella for industrial applications: Advances and prospective, by Feng Chen Carotinoide, by Carola Griehl Engineering the algal chloroplast for synthesis of therapeutic proteins, by Saul Purton Design Concepts and recent developments of photobioreactors, by Clemens Posten Efficiency of flat plate reactors, by Mario Tredici Measuring modelling and control, by Olivier Bernard Microalgae in Life Support Systems, by Klaus Slenzka Heterotrophic oil production, by Makato Watanabe

Iptycenes Chemistry: From Synthesis to Applications provides a comprehensive overview of the development of iptycene chemistry in the past seventy years. This book covers: (1) the basic nomenclature and general properties of iptycenes and their derivatives; (2) the synthesis and functionalization reactions of triptycenes, pentiptycenes, higher iptycenes, heterotriptycenes, and homotriptycenes; (3) the methods for the preparation of iptycene-based polymers with different types; and (4) the applications of iptycenes and their derivatives in molecular machines, materials science, host-guest chemistry, self-assembly, coordination chemistry, physical organic chemistry, medicinal chemistry, and so on. Consequently, such a book is not only helpful to researchers working in iptycene chemistry, but can also facilitate future research in wide areas.

Deng Feng Wang was born February 8, 1965 in Chongqing City, China and died August 15, 1999 while swimming with friends in the Atlantic Ocean off Island Beach State Park, New Jersey. In his brief life, he was to have an influence far beyond his years. On August 12th 2000, The Deng Feng Wang Memorial Conference was held at his alma mater, Princeton University, during which Deng Feng's mentors, collaborators and friends presented scientific talks in a testimonial to his tremendous influence on their work and careers. The first part of this volume contains proceedings contributions from the conference, with plenary talks by Nobel Laureate Professor Phil Anderson of Princeton University and leading Condensed Matter Theorists Professor Piers Coleman of Rutgers University and Professor Christian Gruber of the University of Lausanne. Other talks, given by collaborators, friends and classmates testify to the great breadth of Deng Feng Wang's influence, with remarkable connections shown between seemingly unrelated areas in physics such as Condensed Matter Physics, Superconductivity, One-Dimensional Models, Statistical Physics, Mathematical Physics, Quantum Field Theory, High Energy Theory, Nuclear Magnetic Resonance, Supersymmetry, M-Theory and String Theory, in addition to such varied fields outside of physics such as Oil Drilling, Mixed Signal Circuits and Neurology. The second part of the volume consists of reprints of some of Deng Feng Wang's most important papers in the areas of Condensed Matter Physics, Statistical Physics, Magnetism, Mathematical Physics and Mathematical Finance. This volume represents a fascinating synthesis of a wide variety of topics, and ultimately points to the universality of physics and of science as a whole. As such, it represents a fitting tribute to a remarkable individual, whose tragic death will never erase his enduring influence.

The most comprehensive and conceptual one-volume treatment of this field available and the first to emphasize the cellular and molecular aspects of gut peptide biology. Authored by an array of internationally distinguished scientists, it deals with issues of peptide localization and biosynthesis in gastrointestinal cells, mechanisms of peptide release and inactivation and the nature of peptide receptors. The breadth and readability make it an invaluable reference source for scientists in all disciplines interested in any aspect of brain-gut peptides.

Deng Feng Wang was born February 8, 1965 in Chongqing City, China and died August 15, 1999 while swimming with friends in the Atlantic Ocean off Island Beach State Park, New Jersey. In his brief life, he was to have an influence far beyond his years. On August 12th 2000, The Deng Feng Wang Memorial Conference was held at his alma mater, Princeton University, during which Deng Feng's mentors, collaborators and friends presented scientific talks in a testimonial to his tremendous influence on their work and careers. The first part of this volume contains proceedings contributions from the conference, with plenary talks by Nobel Laureate Professor Phil Anderson of Princeton University and leading Condensed Matter Theorists Professor Piers Coleman of Rutgers University and Professor Christian Gruber of the University of Lausanne. Other talks, given by collaborators, friends and classmates testify to the great breadth of Deng Feng Wang's influence, with remarkable connections shown between seemingly unrelated areas in physics such as Condensed Matter Physics, Superconductivity, One-Dimensional Models, Statistical Physics, Mathematical Physics, Quantum Field Theory, High Energy Theory, Nuclear Magnetic Resonance, Supersymmetry, M-Theory and String Theory, in addition to such varied fields outside of physics such as Oil Drilling, Mixed Signal Circuits and Neurology. The second part of the volume consists of reprints of some of Deng Feng Wang's most important papers in the areas of Condensed Matter Physics, Statistical Physics, Magnetism, Mathematical Physics and Mathematical Finance. This volume represents a fascinating synthesis of a wide variety of topics, and ultimately points to the universality of physics and of science as a whole. As such, it represents a fitting tribute to a remarkable individual, whose tragic death will never erase his enduring influence.

Algae are important organisms that include seaweeds and a number of single-celled and multicellular microscopic forms. Algae are ubiquitous; they inhabit almost everywhere including oceans, freshwater bodies, rocks, soils, and trees. Man's uses of algae may date back to ancient times. In recent decades, there has been renewed interest in the utilization of algae as sources of health food and high-value chemicals and pharmaceuticals, and for aquaculture, agriculture, and wastewater treatment. Nevertheless, the biotechnological potential of algae is still far from fully exploited, due to a lack of understanding of algal characteristics and culture systems, as well as of advanced research techniques. This book contains selected papers presented at the Fourth Asia-Pacific Conference on Algal Biotechnology held in Hong Kong, on 3-6 July, 2000. Written by experts in the field, this book provides a state-of-the-art account of algal biotechnology research. Topics range from use of algae in agriculture to environmental monitoring and protection, from algal culture systems to production of high-value chemicals and pharmaceuticals by algae, and from algal product purification to gene transformation and regulations. This book is intended for use by researchers and industrialists in the field of algal biotechnology. It will also be an important reference for undergraduate and postgraduate students in biotechnology and food science, as well as in biology in general.

Smart Homes (SH) offer a promising approach to assisted living for the ageing population. Yet the main obstacle to the rapid development and deployment of Smart Home (SH) solutions essentially arises from the nature of the SH field, which is multidisciplinary and involves diverse applications and various stakeholders. Accordingly, an alternative to a one-size-fits-all approach is needed in order to advance the state of the art towards an open SH infrastructure. This book makes a valuable and critical contribution to smart assisted living research through the development of new effective, integrated, and interoperable SH solutions. It focuses on four underlying aspects: (1) Sensing and Monitoring Technologies; (2) Context Interference and Behaviour Analysis; (3) Personalisation and Adaptive Interaction, and (4) Open Smart Home and Service Infrastructures, demonstrating how fundamental theories, models and algorithms can be exploited to solve real-world problems. This comprehensive and timely book offers a unique and essential reference guide for policymakers, funding bodies, researchers, technology developers and managers, end users, carers, clinicians, healthcare service providers, educators and students, helping them adopt and implement smart assisted living systems.

In this book, we collected recent results on the control of underactuated mechanical systems subject to internal uncertainties and external disturbances. The strategy developed is so universal that it is not restricted to a specific system but a large class of underactuated systems. Several benchmark systems are studied in this book, including detailed literature review, system dynamics derivation, control problem formulation, and simulation verification. The control strategy developed in chapter 4 is able to stabilize all these benchmark systems with satisfactory performance regardless of the underactuated dynamics and various uncertainties. The book is written as a text suitable for graduate students in the advanced course for the control of underactuated systems. It also provides valuable tools for researchers and practicing engineers working on the control of underactuated mechanical systems.

Iptycenes Chemistry: From Synthesis to Applications provides a comprehensive overview of the development of iptycene chemistry in the past seventy years. This book covers: (1) the basic nomenclature and general properties of iptycenes and their derivatives; (2) the synthesis and functionalization reactions of triptycenes, pentiptycenes, higher iptycenes, heterotriptycenes, and homotriptycenes; (3) the methods for the preparation of iptycene-based polymers with different types; and (4) the applications of iptycenes and their derivatives in molecular machines, materials science, host-guest chemistry, self-assembly, coordination chemistry, physical organic chemistry, medicinal chemistry, and so on. Consequently, such a book is not only helpful to researchers working in iptycene chemistry, but can also facilitate future research in wide areas.

Antenna Mutants, Domestication, by Roberto Bassi Heterotrophic Cultivation, by William McCaffrey Chlorella for industrial applications: Advances and prospective, by Feng Chen Carotinoide, by Carola Griehl Engineering the algal chloroplast for synthesis of therapeutic proteins, by Saul Purton Design Concepts and recent developments of photobioreactors, by Clemens Posten Efficiency of flat plate reactors, by Mario Tredici Measuring modelling and control, by Olivier Bernard Microalgae in Life Support Systems, by Klaus Slenzka Heterotrophic oil production, by Makato Watanabe